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TiO2 nanoporous surfaces and their properties
Roček, Vojtěch ; Urbánková, Kateřina (referee) ; Drbohlavová, Jana (advisor)
This thesis is focused on creation nanostructured surfaces of titanium dioxide and the use of photocatalytic activity of these surfaces for antimicrobial applications. The work is divided into nine main chapters, in which the literature search for producing these surfaces, the principle of photocatalysis and their typical specifics was made. These theoretical findings are then used to form such layers, analyzing their chemical and physical properties and practical verification of their antimicrobial activity. This work experimentally verified processes to ensure the increase of antimicrobial activity. The results and findings are discussed in the conclusion.
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Antimicrobial properties of mesenchymal stem cells
Černá, Kristýna ; Hájková, Michaela (advisor) ; Vobořil, Matouš (referee)
Mesenchymal stem cells (MSCs) were first isolated from bone marrow. Since that they were isolated from almost every tissue in the body. MSCs are multipotent cells with many properties including self-renewal, differentiation into the cells of all three germ lines, trophic and immunomodulatory abilities, specific migration to the site of injury and recently discovered antimicrobial properties. This properties make them a good candidate for cell therapy because they can be used in treatment of many diseases including bacterial infections. This thesis brings a summary of all discovered antimicrobial properties of MSCs. It is primarily focused on their direct and indirect antimicrobial effect. The direct effect is mediated by a secretion of antimicrobial substances and the indirect effect includes an impact on the activity and functions of macrophages and neutrophils. Extracellular vesicles derived from MSCs constitute separate chapter because they can have both direct and indirect antimicrobial effect. Keywords: mesenchymal stem cells, antibacterial effect, bacteria, antimicrobial peptides
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Antimikrobiálny efekt semien révy vinnej
Záhora, Adam
The thesis deals with testing the antimicrobial activity of the seed extracts from grapevine, in the research data summary of biologically active substances contained in the vine seed (Vitis vinifera) and brief general characteristic of selected species of microorganisms. In the practical part of thesis was examined antimicrobial effect of seed extracts obtained from grape wine varieties grown in ČR. The first part of thesis deals with the process of producing extract. It was tested nonmethanol extract exposed to oxdiation, fresh methanol and nonmethanol extract in appropriate diluted concentrations. These extracts at 100 %, 50 %, 10 % concentrations were tested by using the agar difusion method, including Escherichia coli, Enterococcus faecalis and Candida tropicalis. All tested microorganisms were inhibited by the grape seed extracts using agar well difusion method and they were cultivated in their optimal conditions for the growth and reproduction after 24 hours and 48 hours. Finally were performed measurings of the inhibition zones.
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TiO2 nanoporous surfaces and their properties
Roček, Vojtěch ; Urbánková, Kateřina (referee) ; Drbohlavová, Jana (advisor)
This thesis is focused on creation nanostructured surfaces of titanium dioxide and the use of photocatalytic activity of these surfaces for antimicrobial applications. The work is divided into nine main chapters, in which the literature search for producing these surfaces, the principle of photocatalysis and their typical specifics was made. These theoretical findings are then used to form such layers, analyzing their chemical and physical properties and practical verification of their antimicrobial activity. This work experimentally verified processes to ensure the increase of antimicrobial activity. The results and findings are discussed in the conclusion.
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